3-Aminophenylboronic acid → N-(3-methyl-5-isoxazolyl)-5-(3-aminophenyl)thiophene-2-sulfonamide

HRID 234451

反応式

HRID 234451 の反応式
[NH2:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[CH:6][CH:7]=1.[CH3:11][C:12]1[CH:16]=[C:15]([NH:17][S:18]([C:21]2[S:22][C:23](Br)=[CH:24][CH:25]=2)(=[O:20])=[O:19])[O:14][N:13]=1>>[CH3:11][C:12]1[CH:16]=[C:15]([NH:17][S:18]([C:21]2[S:22][C:23]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([NH2:1])[CH:3]=3)=[CH:24][CH:25]=2)(=[O:20])=[O:19])[O:14][N:13]=1

参加物

3

反応物 2

HCID 922693-Aminophenylboronic acidHCID 22998516N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide

生成物 1

HCID 22998520N-(3-methyl-5-isoxazolyl)-5-(3-aminophenyl)thiophene-2-sulfonamide

実験手順

N-(3-methyl-5-isoxazolyl)-5-(3-aminophenyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 32C from 3-amino benzene boronic acid (256 mg, 1.87 mmol) and N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide (55 mg, 1.7 mmol). Purification by column chromatography using 15% MeOH/CHCl3 gave 318 mg (56%) of the product.

後処理

  1. customPurification by column chromatography

出典と根拠

ORDレコード
ord-38ae5150a42a48c98c339052384ec2e7
出典データセット
uspto-grants-1997_01
特許番号
US05594021

関連ノート

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