化工社化工社 化学情報印刷レポート · 研究参考用
3-Nitrophenylboronic Acid → N-(3-methyl-5-isoxazolyl)-5-(3-nitrophenyl)thiophene-2-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Nitrophenylboronic Acid | HCID 1677 | — |
| 反応物 | N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide | HCID 22998516 | — |
| 生成物 | N-(3-methyl-5-isoxazolyl)-5-(3-nitrophenyl)thiophene-2-sulfonamide | HCID 22998512 | 21% |
反応手順
N-(3-methyl-5-isoxazolyl)-5-(3-nitrophenyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 32C from 3-nitrobenzene boronic acid (362 mg, 2.17 mmol) and N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide (700 mg, 2.17 mmol). Purification by column chromatography using 10% MeOH/CHCl3 gave 166 mg of the pure sulfonamide (21% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05594021 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-01a0424ff4f7464d85f80cd1ae1faf43 |
| 出典メモ | uspto-grants-1997_01 |