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Calcium Carbonate → 2-Bromo-5-fluorobenzyl alcohol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Calcium Carbonate | HCID 10112 | — |
| 反応物 | 1-Bromo-2-(bromomethyl)-4-fluorobenzene | HCID 517972 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-Bromo-5-fluorobenzyl alcohol | HCID 2773349 | — |
反応手順
2-Bromo-5-fluorobenzylbromide (2.0 g, 7.46 mmol) was dissolved in dioxane (25 mL) and H2O (25 mL), and CaCO3 (3.84 g, 38.39 mmol) was added. The mixture was heated to reflux overnight. The solution was concentrated, and the residue was partitioned between H2O and CH2Cl2. The organic phase was washed with 1N HCl and brine, dried (MgSO4), filtered, and concentrated to afford the title compound. 1H NMR (CDCl3): δ 2.00 (t, 1H), 4.72 (d, 2H), 6.85-6.92 (m, 1H), 7.26 (dd, 1H), 7.48 (dd, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06852711B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-1076bffe427846ac8eb8c24fef4f4f01 |
| 出典メモ | uspto-grants-2005_02 |