Phosphate → 2-Amino-7-isopropyl-4-methyl-benzothiazole-6-thiol

HRID 23460

反応式

HRID 23460 の反応式
[CH:1]([C:4]1[C:12]2[S:11][C:10]([NH2:13])=[N:9][C:8]=2[C:7]([CH3:14])=[CH:6][C:5]=1[S:15]C#N)([CH3:3])[CH3:2].SC[C@H]([C@@H](CS)O)O.P([O-])([O-])([O-])=O>CCO>[NH2:13][C:10]1[S:11][C:12]2[C:4]([CH:1]([CH3:2])[CH3:3])=[C:5]([SH:15])[CH:6]=[C:7]([CH3:14])[C:8]=2[N:9]=1

参加物

5

反応物 3

HCID 1061PhosphateHCID 446094D-1,4-DithiothreitolHCID 154738397-Isopropyl-4-methyl-6-thiocyanato-benzothiazol-2-yl-amine

生成物 1

HCID 225729072-Amino-7-isopropyl-4-methyl-benzothiazole-6-thiol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The title compound was prepared according to General Method 14 using 7-isopropyl-4-methyl-6-thiocyanato-benzothiazol-2-yl-amine (Example L-5; 11.5 g, 43.7 mmol), dithiothreitol (27.0 g, 175 mmol), EtOH (200 mL), and phosphate buffer (50 mL). MS (APCI): 239 (M+H).

出典と根拠

ORDレコード
ord-10295e2b277a470283758c831ee5ebe7
出典データセット
uspto-grants-2005_02
特許番号
US06852711B2

関連ノート

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