Hydrochloric Acid → 4-(4-Fluorophenyl)cyclohexan-1-one

HRID 234620ノート

反応式

HRID 234620 の反応式
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:18][CH2:17][C:12]3(OCC[O:13]3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1>CO>[F:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:10][CH2:11][C:12](=[O:13])[CH2:17][CH2:18]2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 128344048-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

生成物 1

HCID 128343224-(4-Fluorophenyl)cyclohexan-1-one収率 87%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

Hydrochloric acid (0.75 ml) was added to a solution 8-(4-fluorophenyl)-1,4-dioxaspiro[4,5]decane (10 mmole) in 66% methanol (100 ml). After stirring for 2 hr the methanol was removed in in vacuo and the residue extracted with methylene chloride. Removal of the methylene chloride in vacuo gave the product as an oil (87%).

後処理

  1. customwas removed in in vacuo
  2. extractionthe residue extracted with methylene chloride
  3. customRemoval of the methylene chloride in vacuo

出典と根拠

ORDレコード
ord-4b16ffe0ef884a238506b7f28a5f0de7
出典データセット
uspto-grants-1997_01
特許番号
US05595993

反応ノート

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