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Triethylamine → HCID 15279352、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Chloro-5-methoxy-6-(methoxymethyl)pyrimidine | HCID 15279350 | — |
| 反応物 | HCID 15279351 | HCID 15279351 | — |
| 溶媒 | Toluene water | HCID 22272177 | — |
| 生成物 | HCID 15279352 | HCID 15279352 | — |
反応手順
3.8 g (20 mmol) of 4-chloro-5-methoxy-6-methoxymethylpyrimidine (DE-A 4 116 089), 3.1 g (20 mmol) of 4-iso-butylidene-cyclohexylamine and 3.0 g (30 mmol) of triethylamine were stirred for 3 hours without solvent at 80°-90° C. After cooling, the mixture was taken up in water/toluene, and the organic phase was dried and evaporated on a rotary evaporator. Purification by chromatography (silica gel/ethyl acetate) gave 2.2 g (36% of theory) of a virtually colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05595992 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-8512c949f59e488294e44de880c15aaa |
| 出典メモ | uspto-grants-1997_01 |