Phosphate → 6-tert-Butyl-5-mercapto-2,3-dihydro-indole-1-carboxylic Acid Tert-Butyl Ester

HRID 23478

反応式

HRID 23478 の反応式
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([S:21]C#N)=[C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].SC[C@H]([C@@H](CS)O)O.P([O-])([O-])([O-])=O>CCO>[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([SH:21])=[C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 1061PhosphateHCID 446094D-1,4-DithiothreitolHCID 543438496-tert-Butyl-5-thiocyanato-2,3-dihydro-indole-1-carboxylic Acid Tert-Butyl Ester

生成物 1

HCID 540779236-tert-Butyl-5-mercapto-2,3-dihydro-indole-1-carboxylic Acid Tert-Butyl Ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The title compound was prepared according to General Method 14 using 6-tert-butyl-5-thiocyanato-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (prepared in Example KK; 2.0 g, 6.6 mmol), dithiothreitol (1.21 g, 7.9 mmol), EtOH (100 mL), and phosphate buffer (pH: 7.5, 10 mL). The crude product was used without any purification.

後処理

  1. customThe crude product was used without any purification

出典と根拠

ORDレコード
ord-4785ced226c74426bde033d537ae8572
出典データセット
uspto-grants-2005_02
特許番号
US06852711B2

関連ノート

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