Benzoyl chloride → 3-(Benzoyloxy)-4-methyl-1,3-thiazole-2(3H)-thione

HRID 234783ノート

反応式

HRID 234783 の反応式
[OH:1][N:2]1[C:6]([CH3:7])=[CH:5][S:4][C:3]1=[S:8].C(=O)([O-])O.[Na+].[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>O>[C:14]([O:1][N:2]1[C:6]([CH3:7])=[CH:5][S:4][C:3]1=[S:8])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

5

反応物 3

HCID 7412Benzoyl chlorideHCID 3415933-Hydroxy-4-methyl-2(3H)-thiazolethioneHCID 516892Sodium Bicarbonate

生成物 1

HCID 233556233-(Benzoyloxy)-4-methyl-1,3-thiazole-2(3H)-thione

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

0.735 parts of 3-hydroxy-4-methylthiazol-2(3H)-thione were stirred in 50 parts of water and 0.84 parts of sodium hydrogen carbonate. The solution was screened and 0.9 parts of benzoyl chloride were added. The reaction mixture was stirred overnight at room temperature. A precipitate was formed which was separated by filtration, washed with cold water and recrystallised from ethanol to give 3-benzoyloxy-4-methylthiazol-2(3H)-thione, m.pt. 100°-102° C. By analysis the composition was found to be C 52.4% wt; H 3.6% wt; N 5.6% wt and S 25% wt. C11H9NO2S2 requires C 52.6% wt; H 3.6% wt; N 5.6% wt and S 25.5% wt.

後処理

  1. customA precipitate was formed which
  2. customwas separated by filtration
  3. washwashed with cold water
  4. customrecrystallised from ethanol

出典と根拠

ORDレコード
ord-5f57f49aa6a847d080a6a57537929bd9
出典データセット
uspto-grants-1997_01
特許番号
US05596102

反応ノート

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