化工社化工社 化学情報印刷レポート · 研究参考用
Bromine → 5-Isopropyl-2-nitro-4-thiocyanato-phenylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | Sodium Bromide | HCID 253881 | — |
| 反応物 | Sodium thiocyanate | HCID 516871 | — |
| 反応物 | 5-Isopropyl-2-nitroaniline | HCID 22572852 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-Isopropyl-2-nitro-4-thiocyanato-phenylamine | HCID 22572913 | — |
反応手順
The title compound was prepared according to General Method 13 using 5-isopropyl-2-nitro-phenylamine (prepared in Example PP-1; 5.4 g, 30 mmol), sodium thiocyanate (14.6 g, 180 mmol), sodium bromide (3.7 g, 35.99 mmol), bromine (5.75 g, 36.0 mmol), and MeOH (100 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 238 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06852711B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-233cc62428524c4396e8779a88af5ae1 |
| 出典メモ | uspto-grants-2005_02 |