化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl trans-crotonate → Ethyl 4-methyl-1h-pyrrole-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl trans-crotonate | HCID 429065 | — |
| 反応物 | p-Toluol sulfonylmethyliso-cyanide | HCID 86750240 | — |
| 生成物 | Ethyl 4-methyl-1h-pyrrole-3-carboxylate | HCID 235044 | — |
| 生成物 | 3,4-Dimethylpyrrole | HCID 5324584 | — |
反応手順
Based on D. O. Cheng, T. L. Bowman, E. LeGoff, J. Heterocyclic Chem. 13, 1145 (1976), 3,4-dimethylpyrrole was synthesized starting from p-toluol-sulfonylmethyliso-cyanide and crotonic-acid-ethyl-ester. The dimethyl compound was quickly obtained after reduction of the intermediary 3-(ethoxycarbonyl)-4-methylpyrrole, but at only 18% total yield. The material had a melting point of 25°-28° C. H-NMR (CDCl3): 2.04 (s, 6H), 6.50 (d, 2H), 7.33 (s br, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05597471 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-5f12b5c4b65f4ad3aa4980da30b05451 |
| 出典メモ | uspto-grants-1997_01 |