(S)-2,4-diethyl-7-methoxycarbonyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine → (S)-2,4-diethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylic acid

HRID 234915ノート

反応式

HRID 234915 の反応式
[CH2:1]([C@H:3]1[C:8](=[O:9])[N:7]([CH2:10][CH3:11])[C:6]2[CH:12]=[CH:13][C:14]([C:16]([O:18]C)=[O:17])=[CH:15][C:5]=2[O:4]1)[CH3:2]>Cl>[CH2:1]([C@H:3]1[C:8](=[O:9])[N:7]([CH2:10][CH3:11])[C:6]2[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:5]=2[O:4]1)[CH3:2]

参加物

3

反応物 1

HCID 10825426(S)-2,4-diethyl-7-methoxycarbonyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine

生成物 1

HCID 10776998(S)-2,4-diethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylic acid収率 81.7%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A mixture of (S)-2,4-diethyl-7-methoxycarbonyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (1.90 g) in concentrated hydrochloric acid (40 ml) was stirred under reflux for a day. The concentrated hydrochloric acid was distilled off under reduced pressure to give (S)-2,4-diethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylic acid (1.47 g).

後処理

  1. temperatureunder reflux for a day
  2. distillationThe concentrated hydrochloric acid was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-dd073c96401043aeb09e1a4fdf2b4797
出典データセット
uspto-grants-1997_01
特許番号
US05597820

反応ノート

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