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Potassium Carbonate → Methyl 3-amino-6-nitro-1-benzothiophene-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Ethyl Thioglycolate | HCID 12185 | — |
| 反応物 | 2,4-Dinitrobenzonitrile | HCID 554082 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Methyl 3-amino-6-nitro-1-benzothiophene-2-carboxylate | HCID 619888 | 46% |
反応手順
The product from Example 47B (3.73 g, 19.3 mmol) was treated with 1 equivalent ethyl thioglycolate and 1 equivalent K2CO3 in ethanol by the procedure described in Example 41A to yield the title compound (2.35 g, 46%). m.p. 169°-170° C. 1H NMR (300 MHz, DMSO) δ8.90 (d, 1H), 8.37 (d, 1H), 8.20 (dd, 1H), 7.29 (br s, 2H), 4.31 (q, 2H), 1.31 (t, 3H). MS (DCI/NH3) m/e 284 (M+NH4)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05597823 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-d04c0d47fae94a77b33d7e29cc02dd36 |
| 出典メモ | uspto-grants-1997_01 |