化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Carbonate → Methyl 3-amino-7-chlorobenzo[b]thiophene-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Methyl Thioglycolate | HCID 16907 | — |
| 反応物 | 2,3-Dichlorobenzonitrile | HCID 736567 | — |
| 反応物 | Ethyl acetate hexane | HCID 21226206 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 3-amino-7-chlorobenzo[b]thiophene-2-carboxylate | HCID 10633878 | 12% |
反応手順
The product from Example 56B (1.7 g, 10 mmol) was treated with 1 eq of methyl thioglycolate and 1 eq sodium carbonate in methanol as described in Example 41A to give after chromatography (4:1 hexane/EtOAc) the title compound in 12% yield. 1H NMR (300 MHz, CDCl3) d 3.81 (s, 3H), 5.90 (bs, 2H), 7.34 (t, J=8 Hz, 1H), 7.48 (dd, J=8.1 Hz, 1H), 7.56 (dd, J=8,1 Hz, 1H). MS (DCI/NH3) m/e 259 (M+NH4)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05597823 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-2d1f40fbfd304d09b30758f3d71fe289 |
| 出典メモ | uspto-grants-1997_01 |