1-Aminopiperidine → 2,10-dihydro-10-(1-piperidinyl)imidazo[2,1-b]quinazolin-5(3H)-one

反応式

F[C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[C:4]([N:6]1[CH2:10][CH2:9][N:8]=[C:7]1SC)=[O:5].[NH2:17][N:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>COCCOCCOC.O>[N:18]1([N:17]2[C:2]3[C:3](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:4](=[O:5])[N:6]3[CH2:10][CH2:9][N:8]=[C:7]23)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

参加物

実験手順

A solution of 10.0 g (42.0 mmoles) of the product of Example 1 and 25 ml of 1-aminopiperidine in 50 ml of 2-methoxyethyl ether (diglyme) was heated at reflux for 15 hours. The solution as diluted while hot with about 5 ml of water and allowed to cool. The resulting white needles were collected, washed with ethanol, and air-dried to give 8.10 g of 2,10-dihydro-10-(1-piperidinyl)imidazo[2,1-b]quinazolin-5(3H)-one. Melting point 229°-231° C. Total yield 71%.