N-Aminomorpholine → 2,10-dihydro-10-(4-morpholinyl)imidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one

HRID 2350858ノート

反応式

HRID 2350858 の反応式
Cl[C:2]1[C:7]([C:8]([N:10]2[CH2:14][CH2:13][N:12]=[C:11]2SC)=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:17][N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>>[N:18]1([N:17]2[C:2]3[N:3]=[CH:4][CH:5]=[CH:6][C:7]=3[C:8](=[O:9])[N:10]3[CH2:14][CH2:13][N:12]=[C:11]23)[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1

参加物

3

反応物 2

HCID 20315N-AminomorpholineHCID 143871351-(2-Chloropyridine-3-carbonyl)-2-methylthio-2-imidazoline

生成物 1

HCID 143871362,10-dihydro-10-(4-morpholinyl)imidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one収率 52%

反応条件

温度
160 °C

実験手順

A mixture of 5.00 g (19.5 mmoles) of the product of Example 12 and 6.40 g (62.6 mmoles) of N-aminomorpholine was heated in an oil bath at 160° C. for 1 hour. The resulting mixture was cooled and partitioned between methylene chloride and water. The organic layer was dried (sodium sulfate) and concentrated. The crystalline residue was triturated with hexane. The resulting solid was collected to give 2.75 g of 2,10-dihydro-10-(4-morpholinyl)imidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one. Melting point 225°-226° C. Total yield 52%. This compound exhibits the following formula: ##STR9##

後処理

  1. temperatureThe resulting mixture was cooled
  2. custompartitioned between methylene chloride and water
  3. dry with materialThe organic layer was dried (sodium sulfate)
  4. concentrationconcentrated
  5. customThe crystalline residue was triturated with hexane
  6. customThe resulting solid was collected

出典と根拠

ORDレコード
ord-d043a53d9458470d8252831e938c34db
出典データセット
uspto-grants-1989_10
特許番号
US04871732

反応ノート

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