Sulfuric Acid → 2,4,5-Trifluorobenzamide

HRID 2351027

反応式

HRID 2351027 の反応式
[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[CH:6][C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:13]>>[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:13]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 5938132,4,5-Trifluorobenzonitrile

生成物 1

HCID 27769582,4,5-Trifluorobenzamide

実験手順

In 20 ml of 80% sulfuric acid was dissolved 5.8 g of 2,4,5-trifluorobenzonitrile and the mixture was heated under reflux for 30 minutes. After cooling, the reaction mixture was poured into ice-water and extracted with ethyl acetate. The extract was dried over sodium sulfate and the solvent was removed to yield 5.32 g of 2,4,5-trifluorobenzamide.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. temperatureAfter cooling
  4. extractionextracted with ethyl acetate
  5. dry with materialThe extract was dried over sodium sulfate
  6. customthe solvent was removed

出典と根拠

ORDレコード
ord-02bb96cf642d4a6db1a242a2bebdc1e3
出典データセット
uspto-grants-1989_10
特許番号
US04871852

関連ノート

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