Dimethylformamide → 5-Ethyl-2-furaldehyde

HRID 235108

反応式

HRID 235108 の反応式
CN([CH:4]=[O:5])C.O=P(Cl)(Cl)Cl.[CH2:11]([C:13]1[O:14][CH:15]=[CH:16][CH:17]=1)[CH3:12]>>[CH2:11]([C:13]1[O:14][C:15]([CH:4]=[O:5])=[CH:16][CH:17]=1)[CH3:12]

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 185542-EthylfuranHCID 24813Phosphorus oxychloride

生成物 1

HCID 899895-Ethyl-2-furaldehyde収率 68.9%

反応条件

温度
0 °C

実験手順

A sample of DMF (9.3 mL, 120 mmol) was cooled to 0° C. and POCl3 (3.37 g, 22 mmol) was added, the mixture was stirred for 1 hour at 0° C., then 2-ethyl furan (1.92 g, 20 mmol) was added. The reaction was quenched by pouring onto ice, and the mixture was stirred for 18 hours. The mixture was extracted with hexane, which was dried over MgSO4 and concentrated to give 1.71 g of the title compound (used without further purification).

後処理

  1. customThe reaction was quenched
  2. additionby pouring onto ice
  3. stirringthe mixture was stirred for 18 hours
  4. extractionThe mixture was extracted with hexane, which
  5. dry with materialwas dried over MgSO4
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-8d178fb4c5434ea987c1f70c41398c35
出典データセット
uspto-grants-1997_01
特許番号
US05597832

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