Naphthalene → 1,4-Dihydro-4-hydroxy-1-oxo-4-(trifluoromethyl)naphthalene

HRID 2351112ノート

反応式

HRID 2351112 の反応式
F[H-]F.[NH4+].[C:5]1(=[O:16])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](=[O:15])[CH:7]=[CH:6]1.C([Si](CC)(CC)[C:20]([F:23])([F:22])[F:21])C.C1C2C(=CC=CC=2)C=CC=1>CN(C)C=O>[OH:16][C:5]1([C:20]([F:23])([F:22])[F:21])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](=[O:15])[CH:7]=[CH:6]1

参加物

6

反応物 4

HCID 931NaphthaleneHCID 85301,4-NaphthoquinoneHCID 4204914Triethyl(trifluoromethyl)silaneHCID 178506426HCID 178506426、化合物

生成物 1

HCID 143435041,4-Dihydro-4-hydroxy-1-oxo-4-(trifluoromethyl)naphthalene

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 74 mg (1.3 mmol) of ground ammonium bifluoride, 174 mg (1.1 mmol) of 1,4-naphthoquinone, and 1 mL of N,N-dimethylformamide was treated with 239 mg (1.3 mmol) of triethyltrifluoromethylsilane and stirred vigorously at room temperature for one hour. Gas chromatographic analysis of the reaction mixture showed that the major naphthalene-desired product was 1,4-dihydro-4-hydroxy-1-oxo-4-trifluoromethylnaphthalene.

出典と根拠

ORDレコード
ord-1692b628dcee4bdead13930ef4a9ef9d
出典データセット
uspto-grants-1989_10
特許番号
US04871877

反応ノート

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