Triethylamine → N-{[5-(Methoxymethyl)-1,2,4-oxadiazol-3-yl]methyl}formamide

HRID 2351312ノート

反応式

HRID 2351312 の反応式
[CH:1]1([C:4]2[O:8][N:7]=[C:6]([CH2:9][N+:10]#[C-:11])[N:5]=2)CC1.C1([C:15]2[O:19]N(C)C(NC=O)N=2)CC1.C(N(CC)CC)C.[O:31]=P(Cl)(Cl)Cl>C(Cl)Cl.O>[CH:11]([NH:10][CH2:9][C:6]1[N:5]=[C:4]([CH2:1][O:19][CH3:15])[O:8][N:7]=1)=[O:31]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 24813Phosphorus oxychlorideHCID 107493421,2,4-Oxadiazole, 5-cyclopropyl-3-(isocyanomethyl)-HCID 867411005-Cyclopropyl-3-formylamino-methyl1,2,4-oxadiazole

生成物 1

HCID 14460545N-{[5-(Methoxymethyl)-1,2,4-oxadiazol-3-yl]methyl}formamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

5-Cyclopropyl-3-isocyanomethyl-1,2,4-oxadiazole A stirred solution of 5-cyclopropyl-3-formylamino-methyl-1,2,4-oxadiazole (60 mmol) and triethylamine (176 mmol) in CH2Cl2 (100 ml) was charged dropwise with POCl3 (60 mmol) at 0° C. The mixture was then left for 30 minutes with stirring at 0° C., whereafter a solution of Na (60 mmol) in H2O (50 ml) was added. The mixture was heated to room temperature, evaporated in vacuo. The residue was treated with ether, decanted and the solution was evaporated to give the title compound as an oil. The oil was processed without any further purification. The compound was characterized by its IR absorbtion band at 2160 cm-1.

後処理

  1. additionwas added
  2. customevaporated in vacuo
  3. additionThe residue was treated with ether
  4. customdecanted
  5. customthe solution was evaporated

出典と根拠

ORDレコード
ord-19957d3343934eab8021677ad444dc5c
出典データセット
uspto-grants-1989_10
特許番号
US04873244

反応ノート

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