Triethyl orthoacetate → N-(1-Ethoxyethylidene)-3-(2-chlorophenyl)-1,2,4-thiadiazole-5-sulfonamide

HRID 2351357ノート

反応式

HRID 2351357 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([S:13]([NH2:16])(=[O:15])=[O:14])[S:10][N:9]=1.[C:17](OCC)(OCC)([O:19][CH2:20][CH3:21])[CH3:18]>>[CH2:17]([O:19][C:20](=[N:16][S:13]([C:11]1[S:10][N:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[N:12]=1)(=[O:14])=[O:15])[CH3:21])[CH3:18]

参加物

3

反応物 2

HCID 66221Triethyl orthoacetateHCID 141831363-(2-Chlorophenyl)-1,2,4-thiadiazole-5-sulfonamide

生成物 1

HCID 53969492N-(1-Ethoxyethylidene)-3-(2-chlorophenyl)-1,2,4-thiadiazole-5-sulfonamide

実験手順

A mixture of 3 g of 3-(2-chlorophenyl)-1,2,4-thiadiazole-5-sulfonamide and 11 ml of triethyl orthoacetate was warmed to reflux for 3.5 hours. The mixture was cooled, triturated with hexane (25 ml) and filtered to give 3.13 g of solid, m.p. 70°-72° C.

後処理

  1. temperaturewas warmed
  2. temperatureto reflux for 3.5 hours
  3. temperatureThe mixture was cooled
  4. customtriturated with hexane (25 ml)
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-ca968de37642459baecb021898ec295c
出典データセット
uspto-grants-1989_10
特許番号
US04873239

反応ノート

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