Triethylamine → [4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl][(4-morpholinyl)thio]amine

HRID 2351539

反応式

HRID 2351539 の反応式
[N:1]1([S:7]Cl)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[F:16][C:17]1[CH:23]=[C:22]([O:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:26]=2[Cl:35])[CH:21]=[CH:20][C:18]=1[NH2:19]>C(OCC)C>[Cl:35][C:26]1[CH:27]=[C:28]([C:31]([F:32])([F:34])[F:33])[CH:29]=[CH:30][C:25]=1[O:24][C:22]1[CH:21]=[CH:20][C:18]([NH:19][S:7][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[C:17]([F:16])[CH:23]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 122977794-Morpholinesulfenyl chlorideHCID 15595105Benzenamine, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-2-fluoro-

生成物 1

HCID 15085830[4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl][(4-morpholinyl)thio]amine収率 59.3%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒3 回

実験手順

The compound prepared in Example 5 (3.4 g) was dissolved in diethyl ether (10 ml). The solutionwas added to a solution of triethylamine (2.2 g) and the compound prepared in Example 1 (6.1 g) in diethyl ether (50 ml) at 15°-20° C. The solution was stirred for 20 minutes, diethyl ether was added (20 ml), the solution was washed with water, and dried. The solvent was removed by evaporation. Column chromatogrpahy on silica using 50:50 (v/v) diethyl ether-dichloromethane as eluant yielded the title compound as a brown oil (5 g).

後処理

  1. customat 15°-20° C
  2. washthe solution was washed with water
  3. customdried
  4. customThe solvent was removed by evaporation

出典と根拠

ORDレコード
ord-4a29b51441144cc298ec7642f6f5aff3
出典データセット
uspto-grants-1989_10
特許番号
US04873327

関連ノート

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