Methanol → Methyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

HRID 2352037

反応式

HRID 2352037 の反応式
[CH:1]1([C:9]([OH:11])=[O:10])[CH2:5][CH2:4][N:3]2[CH:6]=[CH:7][CH:8]=[C:2]12.[CH3:12]O>Cl>[CH:1]1([C:9]([O:11][CH3:12])=[O:10])[CH2:5][CH2:4][N:3]2[CH:6]=[CH:7][CH:8]=[C:2]12

参加物

4

反応物 2

HCID 887MethanolHCID 127951052,3-Dihydro-1h-pyrrolizine-1-carboxylic acid

生成物 1

HCID 12795075Methyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid is dissolved in methanol containing a small amount of concentrated hydrochloric acid. The resulting solution is heated to reflux, and then cooled. The title compound is isolated by rotary evaporation of the solvent under reduced pressure, and may be purified by chromatography on silica gel with hexane/ethyl acetate as eluent.

後処理

  1. temperatureThe resulting solution is heated
  2. temperatureto reflux
  3. temperaturecooled

出典と根拠

ORDレコード
ord-586d422b14554575a5537722250183b1
出典データセット
uspto-grants-1989_10
特許番号
US04874871

関連ノート

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