Diethyl Ether → 12-acetyl-5-hydroxy-12H-benzo[a]phenothiazine

HRID 2352216ノート

反応式

HRID 2352216 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[OH:5][C:6]1[CH:19]=[C:18]2[C:9]([NH:10][C:11]3[C:16]([S:17]2)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[C:8]2[CH:20]=[CH:21][CH:22]=[CH:23][C:7]=12.C(OCC)C>CN(C=O)C>[C:1]([N:10]1[C:9]2[C:18](=[CH:19][C:6]([OH:5])=[C:7]3[CH:23]=[CH:22][CH:21]=[CH:20][C:8]3=2)[S:17][C:16]2[C:11]1=[CH:12][CH:13]=[CH:14][CH:15]=2)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 6367Acetyl chlorideHCID 137124785-hydroxy-12H-benzo[a]phenothiazine

生成物 1

HCID 1371248512-acetyl-5-hydroxy-12H-benzo[a]phenothiazine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Acetyl chloride (2 ml) was added to a solution of 5-hydroxy-12H-benzo[a]phenothiazine (1) (2.65 gm) in DMF (10 ml) and stirred for 30 minutes. Diethyl ether (100 ml) was added to the reaction mixture followed by ice-water (50 ml). The aqueous layer was decanted and the organic layer containing a solid was evaporated to dryness. The resulting residue was treated with acetone and filtered to afford the title compound.

後処理

  1. customThe aqueous layer was decanted
  2. additionthe organic layer containing a solid
  3. customwas evaporated to dryness
  4. additionThe resulting residue was treated with acetone
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-3450c869296a464fb7853a16f0984498
出典データセット
uspto-grants-1989_10
特許番号
US04876246

反応ノート

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