Dimethyl Sulfate → Ethyl 4-methyl-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxylate

HRID 2352535ノート

反応式

HRID 2352535 の反応式
S(OC)(O[CH3:5])(=O)=O.[OH:8][C:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][N:12]=[C:11]2[CH:20]=[CH:21][S:22][C:10]=12.[OH-].[K+]>O>[CH3:5][N:12]1[CH:13]=[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:9](=[O:8])[C:10]2[S:22][CH:21]=[CH:20][C:11]1=2

参加物

5

反応物 3

HCID 6497Dimethyl SulfateHCID 14797Potassium HydroxideHCID 178469639HCID 178469639、化合物

生成物 1

HCID 22250098Ethyl 4-methyl-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxylate

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Dimethyl sulphate (3.9 ml) was added to a stirred solution of ethyl 7-hydroxythieno[3,2-b]-pyridine-6-carboxylate (4.63 g) and potassium hydroxide (3.5 g) in water (50 ml) at 0°-5°. More water (20 ml) was added and the mixture was stirred at ambient temperature for 24 hours. The solid product was collected by filtration, washed with water and dried to give the novel compound ethyl 4-methyl-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxylate, m.p. 122°-128°.

後処理

  1. filtrationThe solid product was collected by filtration
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-64cf8c7b7c7f4cf4b4bb36f07678b950
出典データセット
uspto-grants-1989_10
特許番号
US04877793

反応ノート

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