Potassium Hydroxide → 4-{[1,1'-Biphenyl]-4-yl}butanoic acid

HRID 2352573ノート

反応式

HRID 2352573 の反応式
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>C(O)C.O>[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 19843451Ethyl 4-([1,1'-biphenyl]-4-yl)butanoate

生成物 1

HCID 111392304-{[1,1'-Biphenyl]-4-yl}butanoic acid収率 97.2%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

A solution of ethyl 4-(4-phenylphenyl)butanoate (21.0 g) and potassium hydroxide (9.65 g) in ethanol (50 ml) and water (50 ml) was heated under reflux for 2 hours. The resulting mixture was allowed to cool, diluted with water (150 ml), washed with ether (x2), acidified with concentrated hydrochloric acid, and extracted with ether. The extracts were washed with water, dried and concentrated to give crude 4-(4-phenylphenyl)butanoic acid [(3), 18.28 g] as a white solid, m.p. 111°-113° C. (D. H. Hey and R. Wilkinson, J. Chem. Soc., 1940, 1030, give a m.p. of 118°-119° C. for this acid).

後処理

  1. temperatureunder reflux for 2 hours
  2. temperatureto cool
  3. washwashed with ether (x2)
  4. extractionextracted with ether
  5. washThe extracts were washed with water
  6. customdried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-c681ead0eda746aa8570a9e5697af6f5
出典データセット
uspto-grants-1989_10
特許番号
US04877811

反応ノート

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