Ammonia → 2-[4-(Benzyloxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]acetamide

HRID 2352629ノート

反応式

HRID 2352629 の反応式
C([O:8][C:9](=O)[CH2:10][N:11]1[CH2:15][C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:13][C:12]1=[O:24])C1C=CC=CC=1.[NH3:26]>CO>[CH2:17]([O:16][C:14]1[CH2:15][N:11]([CH2:10][C:9]([NH2:26])=[O:8])[C:12](=[O:24])[CH:13]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 142744714-Benzyloxy-3-pyrrolin-2-on-1-yl acetic acid benzyl ester

生成物 1

HCID 142744722-[4-(Benzyloxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]acetamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

25.0 g of 4-benzyloxy-3-pyrrolin-2-on-1-yl acetic acid benzyl ester was dissolved in 500 ml of methanol and stirred at 40° C with passing of gaseous NH3 for 5 hours. Then the reaction solution was evaporated and the residue was mixed with 50 ml of acetone. The precipitated crystals were filtered by suction and dried. 15.2 g of TLC pure product with a melting point of 174.5 to 175.5° C. was obtained. For the product:

後処理

  1. customThen the reaction solution was evaporated
  2. additionthe residue was mixed with 50 ml of acetone
  3. filtrationThe precipitated crystals were filtered by suction
  4. customdried
  5. custom15.2 g of TLC pure product with a melting point of 174.5 to 175.5° C. was obtained

出典と根拠

ORDレコード
ord-d8f00175814e4af2a2c1485ee4c1aa50
出典データセット
uspto-grants-1989_10
特許番号
US04877884

反応ノート

読み込み中…