反応式
[CH2:1]([O:5][CH2:6][CH2:7][S:8][CH2:9][CH:10]1[CH2:12][O:11]1)[CH2:2][CH2:3][CH3:4].CC(C)([O-])C.[K+]>>[CH2:1]([O:5][CH2:6][CH2:7][S:8][CH:9]=[CH:10][CH2:12][OH:11])[CH2:2][CH2:3][CH3:4].[CH:1]([OH:5])=[CH:2][CH3:3]参加物
4
実験手順
Following the procedure of Example 10, 2-butoxyethyltosylate (26.85 g, 98.7 mmol) and 3-mercapto-1,2-propanediol (10.68 g, 98.7 mmol) are reacted together to give 3-(2-butoxyethylthio)-1,2-propanediol, which diol (10.0 g, 52.5 mmol) is reacted with tosyl chloride (10.0 g) in pyridine. The tosylate (9.27 g, 25.6 mmol) is reacted with NaOH (1.02 g, 25.6 mmol) to give 2-(2-butoxyethylthiomethyl)oxirane. The oxirane (1.0 g, 5.26 mmol) and potassium t-butoxide (0.18 g, 1.58 mmol) are reacted together to give 3-(2-butoxyethylthio)-2-propenol, which propenol (4.72 g, 25.0 mmol) is reacted with acetic anhydride to give 3-(2-butoxyethylthio)-2-propenyl acetate.
出典と根拠
- ORDレコード
- ord-7d88d35363c1442a9e293b6e08f663b4
- 出典データセット
- uspto-grants-1989_10
- 特許番号
- US04877899
関連ノート
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