4-((S)-2-hydroxy-propylamino)-2-methylsulfanyl pyrimidine-5-methanol → 4-((S)-2-hydroxy-propylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde

HRID 2353305ノート

反応式

HRID 2353305 の反応式
[OH:1][C@@H:2]([CH3:15])[CH2:3][NH:4][C:5]1[C:10]([CH2:11][OH:12])=[CH:9][N:8]=[C:7]([S:13][CH3:14])[N:6]=1>[O-2].[O-2].[Mn+4].ClCCl>[OH:1][C@@H:2]([CH3:15])[CH2:3][NH:4][C:5]1[C:10]([CH:11]=[O:12])=[CH:9][N:8]=[C:7]([S:13][CH3:14])[N:6]=1

参加物

4

反応物 1

HCID 596814384-((S)-2-hydroxy-propylamino)-2-methylsulfanyl pyrimidine-5-methanol

生成物 1

HCID 596814334-((S)-2-hydroxy-propylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde収率 72.6%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

4-((S)-2-hydroxy-propylamino)-2-methylsulfanyl pyrimidine-5-methanol (26 g, 100 mmol) and 1 L of dichloromethane were combined with stirring and treated with manganese dioxide (102 g, 1 mol). The resulting suspension was stirred for 24 hours and then filtered through celite. The filter residue was washed with dichloromethane (100 mL) and the combined filtrate and washings were evaporated under reduced pressure to give 16.5 g of the 4-((S)-2-hydroxy-propylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde as a white solid.

後処理

  1. stirringThe resulting suspension was stirred for 24 hours
  2. filtrationfiltered through celite
  3. washThe filter residue was washed with dichloromethane (100 mL)
  4. customthe combined filtrate and washings were evaporated under reduced pressure

出典と根拠

ORDレコード
ord-2cacce34121d4f1fbb7b6077cb8c889b
出典データセット
uspto-grants-2010_07
特許番号
US07750016B2

反応ノート

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