化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 7-Fluoro-2,3-dihydro-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 7-Fluoro-1H-indole | HCID 2774504 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 7-Fluoro-2,3-dihydro-1H-indole | HCID 16768261 | 54.2% |
反応手順
7-fluoroindole (2.0 g, 14.8 mmol) was dissolved in acetic acid (6 mL) and sodium cyanoborohydride (1.87 g, 29.6 mmol) was added in 5 portions. The mixture was stirred for 1 hour then poured into 150 mL of 2N NaOH. The mixture was extracted with methylene chloride. The organics were combined, washed with brine, dried over anhydrous magnesium sulfate, and concentrated to give 7-fluoroindoline (1.1 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07750038B2 |
| 出典データセット | uspto-grants-2010_07 |
| ORD ID | ord-74bf08cac423424aa246f19a619d4605 |
| 出典メモ | uspto-grants-2010_07 |