化工社化工社 化学情報印刷レポート · 研究参考用
Morpholine → 4-(4-Nitropyridin-2-yl)morpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 4-Nitropyridine | HCID 70734 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(4-Nitropyridin-2-yl)morpholine | HCID 57418546 | 56.5% |
反応手順
To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07749999B2 |
| 出典データセット | uspto-grants-2010_07 |
| ORD ID | ord-2980c9148a43422cb224823d9fcf9fe8 |
| 出典メモ | uspto-grants-2010_07 |