Potassium Carbonate → 5-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzene

HRID 2353552ノート

反応式

HRID 2353552 の反応式
[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:16]([O-])([O-])=O.[K+].[K+]>CC(C)=O>[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([O:14][CH3:16])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 574185474-tert-Butyl-2-methyl-6-nitro-phenol

生成物 1

HCID 213537455-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzene収率 99%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
60 °C

実験手順

4-tert-Butyl-2-methyl-6-nitro-phenol (209 mg, 1 mmol) was dissolved in 3 mL acetone. 552 mg K2CO3 (4 eq) was added, followed by addition of Mel (0.33 mL, 5 mmol). The reaction mixture was stirred vigorously at 60° C. overnight. After removal of the acetone, the residue was shaken with DCM. Filtration and evaporation of the solution yielded 221 mg product which was used as such.

後処理

  1. additionfollowed by addition of Mel (0.33 mL, 5 mmol)
  2. customAfter removal of the acetone
  3. stirringthe residue was shaken with DCM
  4. filtrationFiltration and evaporation of the solution

出典と根拠

ORDレコード
ord-808fd4c818db4aa5a942663546da28f9
出典データセット
uspto-grants-2010_07
特許番号
US07749999B2

反応ノート

読み込み中…