Triethylamine → N-(4-cyano-3-(trifluromethyl)phenyl)-2-ethoxybenzamide

HRID 2353803ノート

反応式

HRID 2353803 の反応式
[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9](CCCCCCCCCCCCCCC)[C:5]=1[C:6](Cl)=[O:7])[CH3:2].[NH2:28][C:29]1[CH:36]=[CH:35][C:32]([C:33]#[N:34])=[C:31]([C:37]([F:40])([F:39])[F:38])[CH:30]=1.C(N(CC)CC)C>ClCCl>[C:33]([C:32]1[CH:35]=[CH:36][C:29]([NH:28][C:6](=[O:7])[C:5]2[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=2[O:3][CH2:1][CH3:2])=[CH:30][C:31]=1[C:37]([F:38])([F:39])[F:40])#[N:34]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 5221704-Amino-2-(trifluoromethyl)benzonitrileHCID 102500672-ethoxy-6-pentadecyl-benzoyl Chloride

生成物 1

HCID 68453779N-(4-cyano-3-(trifluromethyl)phenyl)-2-ethoxybenzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-ethoxy-6-pentadecyl-benzoyl chloride was condensed with 4-Amino-2-trifluoromethyl benzonitrile in dichloromethane in presence of triethylamine as acid scavenger to yield N-(4-Cyano-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide. The reaction mixture was then concentrated in vacuo and the residue was extracted into ethyl acetate. The ethyl acetate layer was washed with water and with cold aqueous hydrochloric acid, then dried over sodium sulphate and finally concentrated in vacuo. The residue obtained was chromatographed over silica gel to afford the desired product.

出典と根拠

ORDレコード
ord-a62dd58a486e4c698b6b515e224abdc9
出典データセット
uspto-grants-2010_07
特許番号
US07750047B2

反応ノート

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