Piperidine → p-Piperidinophenol

HRID 2354032ノート

反応式

HRID 2354032 の反応式
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:7]1(=O)[CH2:12][CH2:11][C:10](=[O:13])[CH2:9][CH2:8]1>C(O)C>[OH:13][C:10]1[CH:11]=[CH:12][C:7]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 8082PiperidineHCID 125111,4-Cyclohexanedione

生成物 1

HCID 90452p-Piperidinophenol収率 53.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

0.85 g of piperidine and 2.24 g of 1,4-cyclohexanedione were heated with stirring in 15 ml of ethanol at 50 to 60° C. and reacted in air for 8 hours. During the reaction, ethanol was added as needed. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure and the resultant was separated by silica gel column chromatography (n-hexane:ethyl acetate=2:1) and 0.95 g of 1-(4-hydroxyphenyl)piperidine was obtained (yield 53.7%).

後処理

  1. customreacted in air for 8 hours
  2. additionwas added
  3. customAfter the completion of the reaction
  4. concentrationthe reaction mixture was concentrated under reduced pressure
  5. customthe resultant was separated by silica gel column chromatography (n-hexane:ethyl acetate=2:1)

出典と根拠

ORDレコード
ord-ebb719dd853f4f03b43312b907521a64
出典データセット
uspto-grants-2010_07
特許番号
US07750156B2

反応ノート

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