2-(4-Benzylpiperidin-1-yl)ethan-1-amine → 1-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-3-(2,6-dimethyl-pyridin-4-yl)-urea

HRID 2354073ノート

反応式

HRID 2354073 の反応式
[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][C:18]1[CH:23]=[C:22]([NH:24][C:25](NC2C=C(C)N=C(C)C=2)=[O:26])[CH:21]=[C:20]([CH3:36])[N:19]=1>O1CCOCC1>[CH2:1]([CH:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][NH:16][C:25]([NH:24][C:22]2[CH:23]=[C:18]([CH3:17])[N:19]=[C:20]([CH3:36])[CH:21]=2)=[O:26])[CH2:12][CH2:13]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 27798312-(4-Benzylpiperidin-1-yl)ethan-1-amineHCID 593811911,3-Bis-(2,6-dimethyl-pyridin-4-yl)-urea

生成物 1

HCID 112686091-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-3-(2,6-dimethyl-pyridin-4-yl)-urea

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A suspension of 2-(4-benzylpiperidino)-1-ethanamine (Example B1, 54.6 mg, 0.25 mmol), TEA (35 μL, 0.25 mmol) and 1,3-bis-(2,6-dimethyl-pyridin-4-yl)-urea (Example B1, 67.6 mg 0.25 mmol) in dioxane (2 mL) is heated at reflux for 24 h. The solvent is evaporated and the residue purified by HPLC to provide the title compound.

後処理

  1. temperatureis heated
  2. temperatureat reflux for 24 h
  3. customThe solvent is evaporated
  4. customthe residue purified by HPLC

出典と根拠

ORDレコード
ord-e85a7bea8fe44e78ad591894a1e7ec73
出典データセット
uspto-grants-2010_07
特許番号
US07750161B2

反応ノート

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