Hydrochloric Acid → (2E)-3-[5-({(3R)-1-[2-(dimethylamino) benzyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-hydroxyacrylamide trihydrochloride

HRID 2354103ノート

反応式

HRID 2354103 の反応式
[CH3:1][N:2]([CH3:34])[C:3]1[CH:33]=[CH:32][CH:31]=[CH:30][C:4]=1[CH2:5][N:6]1[CH2:10][CH2:9][C@@H:8]([NH:11][C:12]2[N:13]=[CH:14][C:15](/[CH:18]=[CH:19]/[C:20]([NH:22][O:23]C3CCCCO3)=[O:21])=[N:16][CH:17]=2)[CH2:7]1.[ClH:35]>CO.CCO>[ClH:35].[ClH:35].[ClH:35].[CH3:34][N:2]([CH3:1])[C:3]1[CH:33]=[CH:32][CH:31]=[CH:30][C:4]=1[CH2:5][N:6]1[CH2:10][CH2:9][C@@H:8]([NH:11][C:12]2[N:13]=[CH:14][C:15](/[CH:18]=[CH:19]/[C:20]([NH:22][OH:23])=[O:21])=[N:16][CH:17]=2)[CH2:7]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 86628129(2E)-3-[5-({(3R)-1-[2-(dimethylamino)benzyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide

生成物 1

HCID 136381712(2E)-3-[5-({(3R)-1-[2-(dimethylamino) benzyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-hydroxyacrylamide trihydrochloride

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 887Methanol溶媒

実験手順

To a solution of (2E)-3-[5-({(3R)-1-[2-(dimethylamino)benzyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (236 mg) in MeOH (3.5 mL) was added 2N—HCl solution in EtOH (1.27 mL), which was stirred at room temperature for 1 hour. To the reaction mixture was dropwised IPE (9.4 mL), which was stirred further more 1 hour. The prepicitate was filtered to give (2E)-3-[5-({(3R)-1-[2-(dimethylamino) benzyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-hydroxyacrylamide trihydrochloride as a yellow powder (241 mg).

後処理

  1. stirringwas stirred further more 1 hour
  2. filtrationThe prepicitate was filtered

出典と根拠

ORDレコード
ord-d212853be49347c2bccaf324f8e5ff51
出典データセット
uspto-grants-2010_07
特許番号
US07750155B2

反応ノート

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