戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 2354774作成日：2026年10月27日

tert-Butyl piperazine-1-carboxylate → 4-[6-(2-CYCLOPROPYLETHYLCARBAMOYL)PYRIDAZIN-3-YL]PIPERAZINE-1-CARBOXYLIC Acid T-Butyl Ester

https://huagongshe.com/reaction/2354774

反応式

関与物質

役割名称HCID仕込み量
反応物tert-Butyl piperazine-1-carboxylateHCID 143452—
反応物6-Chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxamideHCID 65561565—
生成物4-[6-(2-CYCLOPROPYLETHYLCARBAMOYL)PYRIDAZIN-3-YL]PIPERAZINE-1-CARBOXYLIC Acid T-Butyl EsterHCID 11624983—

反応手順

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid (2-cyclopropylethyl)amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazine-1-carboxylic acid t-butyl ester, the title compound was obtained as a white solid (47% yield). 1H NMR (400 MHz, CDCl3) δ 8.04-7.95, 6.97, 3.62-3.54, 1.59-1.44, 1.34-1.23, 0.72-0.62, 0.45-0.36, 0.06-0.04. MS (ES+) m/z 376.3 (M+1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07754711B2
出典データセットuspto-grants-2010_07
ORD IDord-707489ec70cf4961b016780ddad8b941
出典メモuspto-grants-2010_07