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HRID 2354822作成日：2026年10月27日

2-Pyridineethanamine → 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-PYRIDIN-2-YLETHYL)AMIDE

https://huagongshe.com/reaction/2354822

反応式

関与物質

役割名称HCID仕込み量
反応物2-PyridineethanamineHCID 75919—
反応物6-{4-[2-(Trifluoromethyl)benzoyl]piperazin-1-yl}pyridazine-3-carbonyl chlorideHCID 86597230—
生成物6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-PYRIDIN-2-YLETHYL)AMIDEHCID 16036094—

反応手順

Following the procedure of Example 28, making variations only as required to use 2-pyridin-2-ylethylamine in place of 2-aminopyridine to react with 6-[4-(2-trifluoromethyl-benzoyl)piperazin-1-yl]pyridazine-3-carbonyl chloride, the title compound was obtained as a white powder (30%). m.p. 151-154° C. 1H NMR (300 MHz, DMSO-d6) δ 9.07, 8.78, 8.43, 7.99-7.61, 7.52, 7.34, 3.79-3.60, 3.35-3.14. MS (ES+) m/z 485.3 (M+1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07754711B2
出典データセットuspto-grants-2010_07
ORD IDord-3b47a47c8f8441e19fdc8e829324b75f
出典メモuspto-grants-2010_07