化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 2-Quinolinemethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Quinolinecarboxaldehyde | HCID 79619 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Quinolinemethanol | HCID 73196 | 88% |
反応手順
A solution of 3.0 g of quinoline-2-carboxaldehyde in 100 ml of ethanol was treated with 750 mg of sodium borohydride and stirred at ambient temperature for 15 min. The resulting solution was neutralized with 1N HCl, concentrated in vacuo, and extracted three times with ethyl acetate. The combined organic layers were dried over Na2SO4 and concentrated to provide 2.65 g (88%) of the crude desired compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05597926 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-406cca3cea0d4fa8bf588e44c8e101ac |
| 出典メモ | uspto-grants-1997_01 |