Hydrochloric Acid → 3-(4-Fluorophenoxy)pyrrolidine

HRID 2355167ノート

反応式

HRID 2355167 の反応式
Cl.C(OC([N:9]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10]1)=O)(C)(C)C>O1CCOCC1.C(O)C>[F:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][CH:11]2[CH2:12][CH2:13][NH:9][CH2:10]2)=[CH:16][CH:17]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 50999115Tert-butyl 3-(4-fluorophenoxy)pyrrolidine-1-carboxylate

生成物 1

HCID 218981593-(4-Fluorophenoxy)pyrrolidine

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

4N hydrogen chloride in dioxane (200 ml) is added to a solution of 3-(4-fluoro-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 5 (39.43 g, 140 mmol) in ethanol (200 ml) and the mixture stirred at room temperature for 18 hours. The solvent is evaporated under vacuum and the residue basified using 4N sodium hydroxide solution (200 ml). The resulting product is extracted using DCM (3×100 ml). The organic extracts are dried (using MgSO4), filtered and evaporated to give the title compound as a light brown oil.

後処理

  1. customThe solvent is evaporated under vacuum
  2. extractionThe resulting product is extracted
  3. dry with materialThe organic extracts are dried (using MgSO4)
  4. filtrationfiltered
  5. customevaporated

出典と根拠

ORDレコード
ord-f74877a49c85405a9d30ffc0c07e2c8b
出典データセット
uspto-grants-2010_07
特許番号
US07754758B2

反応ノート

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