Water → 1-Benzyloxycarbonylmethyl-2,4-dioxopyrimidine

HRID 23555

反応式

HRID 23555 の反応式
[O:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][NH:3]1.Br[CH2:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12].C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[O:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][N:3]1[CH2:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12]

参加物

6

反応物 4

HCID 962WaterHCID 1174UracilHCID 11430Potassium CarbonateHCID 62576Benzyl bromoacetate

生成物 1

HCID 226011191-Benzyloxycarbonylmethyl-2,4-dioxopyrimidine収率 60.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 2,4-dioxopyrimidine (1.0 g) in anhydrous DMF (10 ml) were added benzyl bromoacetate (2.5 g) and potassium carbonate (2.5 g). After stirring at room temperature for 15 hours, the reaction mixture was poured into water and extracted with ethyl acetate. The organic phase was washed with brine and then dried with magnesium sulfate, filtered and evaporated under reduced pressure. The precipitate was washed with diethyl ether to give phenylmethyl 2-(2,4-dioxo-1,3-dihydropyrimidinyl)acetate (1.4 g) as a colorless solid.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic phase was washed with brine
  3. dry with materialdried with magnesium sulfate
  4. filtrationfiltered
  5. customevaporated under reduced pressure
  6. washThe precipitate was washed with diethyl ether

出典と根拠

ORDレコード
ord-0c6dbf2897d04754b15dfbc2d2793da6
出典データセット
uspto-grants-2005_02
特許番号
US06852744B2

関連ノート

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