Hydrochloric Acid → N-[3-(Piperidin-4-ylamino)-phenyl]-acetamide dihydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22](=[O:24])[CH3:23])[CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[ClH:25].[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15]2[CH:16]=[C:17]([NH:21][C:22](=[O:24])[CH3:23])[CH:18]=[CH:19][CH:20]=2)[CH2:12][CH2:13]1参加物
4
実験手順
A solution of 4-(3-acetylamino-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.21 g, 0.63 mmol) in 4 M HCl in dioxane (10 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 234.4 [M+H]+.