Methanol → N-[(4,6-Dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-ethenylbenzenesulfonamide

HRID 235569

反応式

HRID 235569 の反応式
Cl[C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([NH:9][C:10]([NH:12][S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH:22]=[CH2:23])(=[O:15])=[O:14])=[O:11])[N:3]=1.[CH3:24][O-:25].[Na+].[CH3:27][OH:28]>>[CH3:24][O:25][C:2]1[N:7]=[C:6]([O:28][CH3:27])[N:5]=[C:4]([NH:9][C:10]([NH:12][S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH:22]=[CH2:23])(=[O:15])=[O:14])=[O:11])[N:3]=1

参加物

4

反応物 3

HCID 887Methanol2 回HCID 10942334Sodium MethoxideHCID 20218271N-[(4,6-Dichloro-1,3,5-triazin-2-yl)aminocarbonyl]-2-ethenylbenzenesulfonamide

生成物 1

HCID 20218273N-[(4,6-Dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-ethenylbenzenesulfonamide

実験手順

The crude 2-ethenyl-N-[(4,6-dichloro-1,3,5-triazin-2-yl)aminocarbonyl]benzenesulfonamide of Example 6 is contacted with methanol (10 ml) and then with a solution of sodium methoxide (14 mmol) in methanol. The mixture is then stirred at room temperature for 1.5 hours and evaporated to dryness. Subsequently, the residue is taken up in water, filtered to remove unwanted solids, and acidified to precipitate the product. The crystalline product obtained can be purified by chromatography on silica gel or recrystallization to yield the title compound.

後処理

  1. customevaporated to dryness
  2. filtrationfiltered
  3. customto remove unwanted solids
  4. customto precipitate the product
  5. customThe crystalline product obtained can
  6. custombe purified by chromatography on silica gel or recrystallization

出典と根拠

ORDレコード
ord-a2299355c44b47aa9a8b6dbfcd64bebc
出典データセット
uspto-grants-1987_02
特許番号
US04640704

関連ノート

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