4-Cyano-3-ethoxy-1-methyl-5,6,7,8-tetrahydroisoquinolin-8-one → 4-Cyano-3-methoxy-1-methyl-5,6,7,8-tetrahydroisoquinolin-8-one
反応式
C(C1C2CCCCC=2C(C)=NC=1OC)#N.[C:16]([C:18]1[C:27]2[CH2:26][CH2:25][CH2:24][C:23](=[O:28])[C:22]=2[C:21]([CH3:29])=[N:20][C:19]=1[O:30][CH2:31]C)#[N:17]>>[C:16]([C:18]1[C:27]2[CH2:26][CH2:25][CH2:24][C:23](=[O:28])[C:22]=2[C:21]([CH3:29])=[N:20][C:19]=1[O:30][CH3:31])#[N:17]参加物
3
実験手順
4-Cyano-3-methoxy-1-methyl-5,6,7,8-tetrahydroisoquinolin-8-one was prepared from 4-cyano-3-methoxy-1-methyl-5,6,7,8-tetrahydroisoquinoline following essentially the same procedure as that described in Tetrahedron, 1975, 31, 527 for the synthesis of 4-cyano-3-ethoxy-1-methyl-5,6,7,8-tetrahydroisoquinolin-8-one and was obtained as white crystals, mp 128° C. Pmr spectrum (CDCl3 ; δ in ppm): 2.04-3.19 (6H,m); 2.86 (3H,s); 4.12 (3H,s).
後処理
- customwas obtained as white crystals, mp 128° C
出典と根拠
- ORDレコード
- ord-d09af3510d9b4d02a9db0b4e4a589295
- 出典データセット
- uspto-grants-1987_02
- 特許番号
- US04640708
反応ノート
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