3-Chloro-1-methyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile → 3-Chloro-1-methyl-5,6,7,8-tetrahydroisoquinoline-4-carboxaldehyde
反応式
[Cl:1][C:2]1[N:3]=[C:4]([CH3:14])[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[C:11]=1[C:12]#N.[H-].C([Al+]CC(C)C)C(C)C.C(C1C([O:34]C)=NC(C)=CC=1)#N>>[Cl:1][C:2]1[N:3]=[C:4]([CH3:14])[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[C:11]=1[CH:12]=[O:34]参加物
4
実験手順
3-Chloro-1-methyl-5,6,7,8-tetrahydroisoquinoline-4-carboxaldehyde was prepared from 3-chloro-4-cyano-methyl-5,6,7,8-tetrahydroisoquinoline by reduction with diisobutylaluminium hydride following essentially the same procedure as that described in J. Org. chem., 1980, 45, 1354 for the reduction of 3-cyano-2-methoxy-6-methylpyridine. Pmr spectrum (CDCl3 ; δ in ppm): 1.79 (4H,m); 2.47 (3H,s); 2.59-3.18 (4H,m); 10.52 (1H,s).
出典と根拠
- ORDレコード
- ord-487cc02b608140c5ac7a3e3fe2affa87
- 出典データセット
- uspto-grants-1987_02
- 特許番号
- US04640708
反応ノート
読み込み中…