関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acrylic Acid | HCID 6581 | — |
| 反応物 | 4-Bromoanisole | HCID 7730 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 触媒 | Palladium Chloride | HCID 24290 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Methoxy cinnamic acid | HCID 13245 | 81.2% |
反応手順
p-bromo anisole (8.4 g), acrylic acid (3.9 g), water (13.5 g), PdCl2 (0.3 mg) and triethyamine (14.3 g, 89.3% pure by titration, the balance being water, recovered by phase separation from a previous run) were charged into an autoclave and heated for 2 hours at 130° C. The work up detailed in Example 1 gave 6.5 g (81%) of >98% pure p-methoxy cinnamic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05728865 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-623e76f5d131438c908eae7b5ce8e7ac |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
