関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 6-Chloronicotinamide | HCID 80456 | — |
| 生成物 | 4-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine | HCID 11484042 | — |
反応手順
A mixture of 3 g (0.015 mol) of the product of preparation 1, 1.5 g (0.015 mol) of triethylamine and 2.34 g (0.015 mol) of 6-chloronicotinamide in 60 ml of dimethylformamide is heated at 80° C. for 18 hours. After cooling, water is added and the product is filtered off. 2.8 g of the title compound are thus obtained. m.p. 255° C. dec.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06852736B2 |
|---|
| 出典データセット | uspto-grants-2005_02 |
|---|
| ORD ID | ord-cea0b8f2a83640e79fadf2be389be974 |
|---|
| 出典メモ | uspto-grants-2005_02 |
|---|
