In the synthesis of the compound of example 160, the procedure was as in the preparation of the compound of example 158: 2-methyl-4-nitrobenzonitrile was reduced with hydriodic acid (analogously to the procedure for the synthesis of compound 63.4) to 4-amino-2-methylbenzonitrile (160.3; 1H NMR: 7.3, d, 1H, 6.48, s, 1H, 6.42, d, 1H, 6.02, s, 2H; 227, s, 3H). The aniline 160.3 was converted with standard methods using tert-butyl 2-amino-2-methylpropionate hydrochloride and phosgene (solution in toluene) to compound 160.1 (4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-methylbenzonitrile; 1H NMR: 8.7, s, 1H, 7.88, d, 1H, 7.55, s, 1H; 7.44, d, 1H, 1.4, s, 3H), which was in turn reacted with 2-bromo-1-bromomethyl-4-fluorobenzene to give 160.2 (4-[3-(2-bromo-4-fluorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-methylbenzonitrile; molecular weight 429.04 (C20H17BrFN3O2);
