Chloroform methanol → Levcromakalim

HRID 235675

反応式

HRID 235675 の反応式
[C:1]([C:3]1[CH:21]=[CH:20][C:6]2[O:7][C:8]([CH3:19])([CH3:18])[C@@H:9]([OH:17])[C@H:10]([N:11]3[CH2:15][CH2:14][CH2:13][CH:12]3[OH:16])[C:5]=2[CH:4]=1)#[N:2].I([O-])(=O)(=O)=O.[Na+].C(Cl)(Cl)Cl.CO.CCCCCCC.C(OCC)(=O)C.C(N(CC)CC)C>O.CO>[C:1]([C:3]1[CH:21]=[CH:20][C:6]2[O:7][C:8]([CH3:19])([CH3:18])[C@@H:9]([OH:17])[C@H:10]([N:11]3[CH2:15][CH2:14][CH2:13][C:12]3=[O:16])[C:5]=2[CH:4]=1)#[N:2]

参加物

6

反応物 4

HCID 21584188Chloroform methanolHCID 22311133HCID 22311133、化合物HCID 23667635Sodium periodateHCID 67881644HCID 67881644、化合物

生成物 1

HCID 93504Levcromakalim

試薬・触媒・溶媒 1

HCID 22242641Methanol--water (1/1)溶媒

実験手順

6-Cyano-3,4-dihyro-2,2-dimethyl-trans-4-(2-hydroxy-1-pyrrolidinyl)-2H-benzo[b]pyran-3-ol (5 mg), dissolved in methanol water (1 ml) was treated with an excess of sodium periodate with stirring during 15 hours at room temperature. Evaporation of solvents and extraction by ethyl acetate gave material having identical thin layer characteristics when applied to silica gel plates developed in either chloroform-methanol (15:1) or heptane-ethyl acetate-triethylamine and infra red spectrum to the title compound reported in Example 1 of U.S. Pat. No. 4,446,113.

後処理

  1. customEvaporation of solvents and extraction by ethyl acetate
  2. customgave material

出典と根拠

ORDレコード
ord-13ee768044bc4073ace3e7dc76a2bd3e
出典データセット
uspto-grants-1987_02
特許番号
US04640928

関連ノート

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