Acetic Anhydride → 4-Acetoxy-2-fluorobenzoic acid

HRID 2357

反応式

HRID 2357 の反応式
[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[C:12](OC(=O)C)(=[O:14])[CH3:13]>S(=O)(=O)(O)O.O>[C:12]([O:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[CH:10]=1)(=[O:14])[CH3:13]

参加物

5

反応物 2

HCID 7918Acetic AnhydrideHCID 27833982-Fluoro-4-hydroxybenzoic Acid

生成物 1

HCID 227214164-Acetoxy-2-fluorobenzoic acid

試薬・触媒・溶媒 2

HCID 1118Sulfuric Acid触媒HCID 962Water溶媒2 回

反応条件

温度
80 °C

実験手順

4.3 Grams of 2-fluoro-4-hydroxybenzoic acid and 8.4 g of acetic anhydride were placed in a two-necked flask and mixed. While the mixture was cooled with water, 5 drops of sulfuric acid was added. After the heat generation ended, the mixture was heated at 80° C. for 30 minutes. Then, the reaction mixture was poured into cold water, and precipitated crystal was recovered by filtration. The crystal was dried under vacuum and used in a subsequent step. The yield of the crystal was 4.7 g.

後処理

  1. additionmixed
  2. additionwas added
  3. customprecipitated crystal
  4. filtrationwas recovered by filtration
  5. customThe crystal was dried under vacuum

出典と根拠

ORDレコード
ord-83277f5bcbe3453880c179fb06727b5a
出典データセット
uspto-grants-1998_03
特許番号
US05728864

関連ノート

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