Tetrahydropyran → HCID 131715052、化合物

HRID 235711

反応式

HRID 235711 の反応式
[C:1]([NH:4][C@H:5]([C:8]([O:10][CH3:11])=[O:9])[CH2:6][OH:7])(=[O:3])[CH3:2].[O:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>C(Cl)Cl>[C:1]([NH:4][C@H:5]([C:8]([O:10][CH3:11])=[O:9])[CH2:6][O:7][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][O:12]1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 8894TetrahydropyranHCID 7010549N-Acetyl-L-serine methyl ester

生成物 1

HCID 131715052HCID 131715052、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of about 4.50 g of N-acetyl-L-serine, methyl ester in about 100 ml of dry methylene chloride was added about 2.93 ml of distilled tetrahydro-2H-pyran and about 0.34 ml of borontrifluoroetherate. The mixture was stirred under argon for about 7 hours, then washed with saturated sodium bicarbonate and brine, dried and the solvent removed under reduced pressure, giving about 6 g of the desired title compound.

後処理

  1. washwashed with saturated sodium bicarbonate and brine
  2. customdried
  3. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-c052932052e949668d5773d1650e1342
出典データセット
uspto-grants-1987_02
特許番号
US04640913

関連ノート

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